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What is Pyridoxal-5'-Phosphate?

Pyridoxal-5'-phosphate (PLP) is the biologically active coenzyme form of vitamin B6. While many supplements use pyridoxine hydrochloride (a synthetic form that the body must convert to PLP), Nutri-Leaf uses the active form directly, bypassing the need for hepatic conversion. PLP acts as a cofactor for over 140 enzymes involved in amino acid metabolism, neurotransmitter synthesis, homocysteine metabolism, glycogen breakdown, and haemoglobin synthesis.

Vitamin B6 has one of the broadest ranges of function among all vitamins, reflected in its extensive list of EFSA-approved health claims. It is involved in the synthesis of neurotransmitters such as serotonin (mood), dopamine (motivation), and GABA (relaxation), making it relevant for psychological function. B6 also plays a role in the regulation of hormonal activity through its involvement in steroid hormone receptor modulation. The active PLP form is readily utilised by the body without conversion, making it a preferred form for supplementation.

EFSA-approved health benefits

The European Food Safety Authority (EFSA) has confirmed that vitamin B6:

• contributes to normal cysteine synthesis
• contributes to normal energy-yielding metabolism
• contributes to the normal functioning of the nervous system
• contributes to normal homocysteine metabolism
• contributes to normal protein and glycogen metabolism
• contributes to normal psychological function
• contributes to normal red blood cell formation
• contributes to the normal function of the immune system
• contributes to the reduction of tiredness and fatigue
• contributes to the regulation of hormonal activity

Why we use Pyridoxal-5'-Phosphate in Nutri-Leaf formulas

Nutri-Leaf Vitamin B Complex uses the active coenzyme form of vitamin B6 — pyridoxal-5'-phosphate (PLP) — rather than the more common pyridoxine hydrochloride. PLP is immediately available to the body without requiring conversion by the liver. This is particularly beneficial for individuals with reduced liver function or genetic variations in B6 metabolism. Each capsule delivers 1.4mg (100% NRV) in this active form.

Products containing Pyridoxal-5'-Phosphate

The Nutri-Leaf product featuring pyridoxal-5'-phosphate is Vitamin B Complex, which provides all eight B vitamins at 100% NRV per capsule in active, bioavailable forms for comprehensive metabolic, neurological, and immune support.

Discover how active B6 contributes to multiple aspects of health on our Energy & Vitality, Stress Management, and Immune Support guides. Visit the Ingredient Philosophy page for more on our active-form approach.

Food supplements are not a substitute for a balanced and varied diet and a healthy lifestyle.